SYK anticorps (AA 296-484)

N° du produit ABIN1724704

Cet anticorps Souris Monoclonal détecte spécifiquement SYK dans WB et ELISA. Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour SYK anticorps (AA 296-484) (ABIN1724704)

Antigène: SYK (Spleen tyrosine Kinase (SYK))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SYK est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 8C1A3

Détail du produit anti-SYK anticorps

Épitope: AA 296-484

Fonction: SYK Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of SYK (aa296-484) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1/10000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-SYK (ABIN1724704)

Abbal, Lambelet, Bertaggia, Gerbex, Martinez, Arcaro, Schapira, Spertini: "Lipid raft adhesion receptors and Syk regulate selectin-dependent rolling under flow conditions." dans: Blood, Vol. 108, Issue 10, pp. 3352-9, (2006) (PubMed).

Kunze, Wendt, Schlott: "Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas." dans: International journal of molecular medicine, Vol. 18, Issue 4, pp. 547-57, (2006) (PubMed).

Wossning, Herzog, Köhler, Meixlsperger, Kulathu, Mittler, Abe, Fuchs, Borkhardt, Jumaa: "Deregulated Syk inhibits differentiation and induces growth factor-independent proliferation of pre-B cells." dans: The Journal of experimental medicine, Vol. 203, Issue 13, pp. 2829-40, (2006) (PubMed).

Détails sur SYK

Antigène: SYK (Spleen tyrosine Kinase (SYK))

Autre désignation: SYK

Sujet: SYK: spleen tyrosine kinase. Syk (72 kDa) is a non-receptor protein tyrosine kinase that plays an important role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. SYK is a positive effector of BCR stimulated responses. It couples the B cell antigen receptor (BCR) to the mobilization of calcium ions either through a phosphoinositide 3 kinase dependent pathway, when not phosphorylated on tyrosines of the linker region, or through a phospholipase C gamma dependent pathway, when phosphorylated on Tyr 342 and Tyr 346. Thus the differential phosphorylation of SYK can determine the pathway by which BCR is coupled to the regulation of intracellular calcium ions.

UniProt: P43405

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Thromboxane A2 Receptor Signaling, BCR Signaling