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WHSC2 anticorps (AA 280-511)

WHSC2 Reactivité: Humain WB, ELISA, IHC, FACS, ICC Hôte: Souris Monoclonal 6B11H8 unconjugated
N° du produit ABIN1724801
  • Antigène Voir toutes WHSC2 Anticorps
    WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))
    Épitope
    • 8
    • 7
    • 7
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 280-511
    Reactivité
    • 48
    • 16
    • 16
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 33
    • 14
    • 1
    Souris
    Clonalité
    • 37
    • 11
    Monoclonal
    Conjugué
    • 24
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp WHSC2 est non-conjugé
    Application
    • 33
    • 20
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)
    Purification
    purified
    Immunogène
    Purified recombinant fragment of human WHSC2 (AA: 280-511) expressed in E. coli.
    Clone
    6B11H8
    Isotype
    IgG2b
  • Indications d'application
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    4°C, -20°C for long term storage
  • Kerzendorfer, Hannes, Colnaghi, Abramowicz, Carpenter, Vermeesch, ODriscoll: "Characterizing the functional consequences of haploinsufficiency of NELF-A (WHSC2) and SLBP identifies novel cellular phenotypes in Wolf-Hirschhorn syndrome." dans: Human molecular genetics, Vol. 21, Issue 10, pp. 2181-93, (2012) (PubMed).

    Yung, Narita, Komori, Yamaguchi, Handa: "Cellular dynamics of the negative transcription elongation factor NELF." dans: Experimental cell research, Vol. 315, Issue 10, pp. 1693-705, (2009) (PubMed).

  • Antigène
    WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))
    Autre désignation
    WHSC2 (WHSC2 Produits)
    Synonymes
    anticorps BcDNA:SD07139, anticorps CG5874, anticorps Dmel\\CG5874, anticorps NELF, anticorps NELF-A, anticorps Whsc2, anticorps fi75f03, anticorps whsc2, anticorps wu:fi75f03, anticorps MGC85474, anticorps WHSC2, anticorps nelfa, anticorps nelf-a, anticorps p/okcl.15, anticorps Whsc2h, anticorps Negative elongation factor A, anticorps negative elongation factor complex member A, anticorps negative elongation factor complex member A L homeolog, anticorps negative elongation factor complex member A, Whsc2, anticorps Nelf-A, anticorps Nelfa, anticorps nelfa, anticorps nelfa.L, anticorps NELFA
    Sujet

    Description: This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93 % sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. , ,

    Aliases: NELFA, NELF-A, P/OKcl.15

    Poids moléculaire
    57.3 kDa
    ID gène
    7469
    HGNC
    7469
    Pathways
    Chromatin Binding
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