KLF1 anticorps (AA 208-362)
Aperçu rapide pour KLF1 anticorps (AA 208-362) (ABIN1724828)
Antigène
Voir toutes KLF1 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Épitope
- AA 208-362
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Fonction
- KLF1 Antibody
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Purification
- Purified antibody
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Immunogène
- Purified recombinant fragment of human KLF1 (AA: 208-362) expressed in E. Coli.
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Isotype
- IgG1
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Indications d'application
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ELISA: 1/10000
FCM: 1/200 - 1/400
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- 4 °C,-20 °C
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Stockage commentaire
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding." dans: The Journal of biological chemistry, Vol. 286, Issue 28, pp. 24819-27, (2011) (PubMed).
: "KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching." dans: Nature genetics, Vol. 42, Issue 9, pp. 742-4, (2010) (PubMed).
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: "Transcription factors KLF1 and KLF2 positively regulate embryonic and fetal beta-globin genes through direct promoter binding." dans: The Journal of biological chemistry, Vol. 286, Issue 28, pp. 24819-27, (2011) (PubMed).
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- KLF1 (Kruppel-Like Factor 1 (erythroid) (KLF1))
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Autre désignation
- KLF1
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Sujet
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This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype.
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Poids moléculaire
- 38.2 kDa
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UniProt
- Q13351
Antigène
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