CA9 anticorps (AA 37-186)

N° du produit ABIN1724883

Détail du produit anti-CA9 anticorps

Antigène: CA9 (Carbonic Anhydrase IX (CA9))

Épitope: AA 37-186

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CA9 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: purified

Immunogène: Purified recombinant fragment of human CA9 (AA: 37-186) expressed in E. coli.

Clone: 7C4A5

Isotype: IgG1

Information d'application

Indications d'application: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: 4°C, -20°C for long term storage

Références pour anticorps anti-CA9 (ABIN1724883)

Neumeister, Sullivan, Lindner, Lezon-Geyda, Li, Zavada, Martel, Glazer, Tuck, Rimm, Harris: "Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer." dans: Breast cancer research and treatment, Vol. 136, Issue 1, pp. 67-75, (2012) (PubMed).

Pinheiro, Sousa, Albergaria, Paredes, Dufloth, Vieira, Schmitt, Baltazar: "GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prognostic factors and MCT1 overexpression." dans: Histology and histopathology, Vol. 26, Issue 10, pp. 1279-86, (2011) (PubMed).

Détails sur CA9

Antigène: CA9 (Carbonic Anhydrase IX (CA9))

Autre désignation: CA9 (CA9 Produits)

Synonymes: anticorps CA9, anticorps CAIX, anticorps Ca9, anticorps MN/CA9, anticorps MN, anticorps carbonic anhydrase 9, anticorps CA9, anticorps CAH9, anticorps Car9

Sujet:

Description: Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and the only tumor-associated carbonic anhydrase isoenzyme known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12. ,

Aliases: MN, CAIX

Poids moléculaire: 49.7 kDa

ID gène: 768

HGNC: 768