Dynamin 1-Like anticorps (AA 69-213)

N° du produit ABIN1724907

Cet anticorps anti-Dynamin 1-Like est un anticorps Souris Monoclonal détectant Dynamin 1-Like dans WB, ELISA, FACS et ICC. Adapté pour Humain, Souris et Rat. Ce Primary Antibody a été cité dans 2+ publications.

Aperçu rapide pour Dynamin 1-Like anticorps (AA 69-213) (ABIN1724907)

Antigène: Dynamin 1-Like (DNM1L)

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Dynamin 1-Like est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 4A4C7

Détail du produit anti-Dynamin 1-Like anticorps

Épitope: AA 69-213

Fonction: DNM1L Antibody

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human DNM1L (AA: 69-213) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Références pour anticorps anti-Dynamin 1-Like (ABIN1724907)

Thomas, Jacobson: "Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model." dans: PLoS ONE, Vol. 7, Issue 9, pp. e45319, (2012) (PubMed).

Marsboom, Toth, Ryan, Hong, Wu, Fang, Thenappan, Piao, Zhang, Pogoriler, Chen, Morrow, Weir, Rehman, Archer: "Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension." dans: Circulation research, Vol. 110, Issue 11, pp. 1484-97, (2012) (PubMed).

Détails sur Dynamin 1-Like

Antigène: Dynamin 1-Like (DNM1L)

Autre désignation: DNM1L

Sujet: The protein encoded by this gene is a member of the dynamin superfamily of GTPases. Members of the dynamin-related subfamily, including the S. cerevisiae proteins Dnm1 and Vps1, contain the N-terminal tripartite GTPase domain but do not have the pleckstrin homology or proline-rich domains. This protein establishes mitochondrial morphology through a role in distributing mitochondrial tubules throughout the cytoplasm. The gene has 3 alternatively spliced transcripts encoding different isoforms. These transcripts are alternatively polyadenylated.

Poids moléculaire: 81.9 kDa

UniProt: O00429