Reacts with human p53DINP1. Cross-reacts with mouse and rat protein.
Purification
Purified
Immunogène
Peptide corresponding to aa 1-14 of human p53DINP1. This sequence is identical in p53DINP1 alpha and beta and differs from that of mouse p53DINP1 by one amino acid.
Working dilution: Optimal dilutions should be determined by the end user. The following are guidelines only: WB: 1-2 μg/mL
Positive control: Human lung tissue
Restrictions
For Research Use only
Buffer
PBS, pH 7.4
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Dilute in PBS or medium which is identical to that used in the assay system.
Stock
-20 °C
Stockage commentaire
Store in aliquots at -20°C. Antibodies are guaranteed for 6 months from date of receipt.
Date de péremption
6 months
Antigène
TP53INP1
(Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))
Autre désignation
p53DINP1
Sujet
Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response.
Tumor protein p53-inducible nuclear protein 1 Stress-induced protein p53-dependent damage-inducible nuclear protein 1, p53DINP1 Gene name: TP53INP1, P53DINP1, SIP