LGI1 anticorps (AA 37-113) (FITC)

N° du produit ABIN1741281

Cet anticorps anti-LGI1 est un anticorps Souris Monoclonal détectant LGI1 dans WB, IHC, IF et ICC. Adapté pour Souris.

Aperçu rapide pour LGI1 anticorps (AA 37-113) (FITC) (ABIN1741281)

Antigène: LGI1 (Leucine-Rich, Glioma Inactivated 1 (LGI1))

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LGI1 est conjugé à/à la FITC

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: S283-7

Détail du produit anti-LGI1 anticorps (FITC)

Épitope: AA 37-113

Specificité: Detects ~60 kDa.

Réactivité croisée: Humain, Souris, Rat

Purification: Protein G Purified

Immunogène: Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1. Rat: 100% identity (77/77 amino acids identical). Human: 98% identity (76/77 amino acids identical). ~50% identity with LGI2, LGI3 and LGI4.

Isotype: IgG2a

Information d'application

Indications d'application:

• WB (1:1000)
• optimal dilutions for assays should be determined by the user.

Commentaires:

1 μg/ml of ABIN1741281 was sufficient for detection of LGI1 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur LGI1

Antigène: LGI1 (Leucine-Rich, Glioma Inactivated 1 (LGI1))

Autre désignation: LGI1

Sujet: The leucine-rich, glioma inactivated gene 1 (LGI1) was first identified as a candidate tumor suppressor gene for glioma and may play a role in other cancers. LGI1 is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 serves as a ligand to ADAM22, a metalloprotease localized at the synapse. Mutations in LGI1 account for nearly half of autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Two isoforms of LGI1 are known to exist, this LGI1 antibody will recognize only the longer form.

ID gène: 56839

NCBI Accession: NP_064674

UniProt: Q9JIA1