Ataxin 1 anticorps (AA 746-761) (PE)

N° du produit ABIN1741537

Cet anticorps Souris Monoclonal détecte spécifiquement Ataxin 1 dans WB, IF et ICC. Il présente une réactivité envers Souris.

Aperçu rapide pour Ataxin 1 anticorps (AA 746-761) (PE) (ABIN1741537)

Antigène: Ataxin 1 (ATXN1)

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Ataxin 1 est conjugé à/à la PE

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: S65-37

Détail du produit anti-Ataxin 1 anticorps (PE)

Épitope: AA 746-761

Specificité: Detects ~85 kDa. No cross-reactivity against phosphor S751-Ataxin-1. Minimal cross-reactivity against S751A mutant of Ataxin-1 by ELISA and immunofluorescence and negative by immunoblot.

Réactivité croisée: Humain, Souris, Rat

Purification: Protein G Purified

Immunogène: Synthetic peptide amino acids 746-761 (RKRRWSAPETRKLEKS) of mouse ataxin-1. Rat: 93% identity (15/16 amino acids identical). Human: 87% identity (14/16 amino acids identical).

Isotype: IgG1

Information d'application

Indications d'application:

• WB (1:1000)
• optimal dilutions for assays should be determined by the user.

Commentaires:

1 μg/ml of ABIN1741537 was sufficient for detection of Ataxin 1 in 20 μg of COS cells transiently transfected with Ataxin-1 lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur Ataxin 1

Antigène: Ataxin 1 (ATXN1)

Autre désignation: Ataxin 1

Sujet: Ataxin-1 is a member of the ATXN1 protein family and contains a single AXH domain. It is a neurodegenerative disorder protein thought to have a role in the metabolism of RNA as it has been shown to localize to the RNA and transcription dependent inclusions within the nucleus. A mutation of Ataxin-1 is the cause of spinocerebellar ataxia type-1 (SCA1), a progressive, neurodegenerative disease that is autosomal dominant and primarily affects the Purjinke cells found in brain stem neuronal populations and the cerebellum. Expression of Ataxin-1 is almost ubiquitous, except in the brain where it is isolated to populations of neurons.

ID gène: 20238

NCBI Accession: NP_001186233

UniProt: P54254

Pathways: Synaptic Membrane