Alpha, beta Synuclein (AA 2-25) anticorps

N° du produit ABIN1742282

Il existe 7+ publications pour ce produit. L’anticorps anti-Alpha, beta Synuclein Polyclonal Lapin est utilisé pour la détection de Alpha, beta Synuclein dans des échantillons de Humain, Souris, Rat et Poisson zèbre (Danio rerio). Il a été validé pour WB, ICC, IHC, IHC (p) et IP.

Aperçu rapide pour Alpha, beta Synuclein (AA 2-25) anticorps (ABIN1742282)

Antigène: Alpha, beta Synuclein

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Détail du produit

Épitope: AA 2-25

Fonction: Rabbit anti-alpha/beta Synuclein antiserum

Specificité: Recognizes alpha synuclein and beta synuclein.

Réactivité croisée (Details): Reacts with: rat (P37377, Q63754), mouse (O55042, Q91ZZ3), zebrafish, human (P37840, Q16143). Other species not tested yet.

Purification: antiserum

Immunogène: Synthetic peptide corresponding to AA 2 to 25 from human alpha-Synuclein (UniProt Id: P37840)

Information d'application

Indications d'application: WB:1 : 1000 , IP:yes ICC:1 : 500, IHC:1 : 500, IHC-P:1 : 1000 up to 1 : 2000,

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: For reconstitution add 200 μLH2O, then aliquot and store at -20 °C until use.

Conseil sur la manipulation: Do not freeze! Antibodies should be stored at +4°C when still lyophilized.

Stock: -20 °C,4 °C

Stockage commentaire: Antibodies should be stored at +4°C when still lyophilized. Do not freeze!

Référence

Wilhelm, Mandad, Truckenbrodt, Kröhnert, Schäfer, Rammner, Koo, Claßen, Krauss, Haucke, Urlaub, Rizzoli: "Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins." dans: Science (New York, N.Y.), Vol. 344, Issue 6187, pp. 1023-8, (2014) (PubMed).

Siebert, Kahle, Kramer, Isik, Schlüter, Schulz-Schaeffer, Brück: "Over-expression of alpha-synuclein in the nervous system enhances axonal degeneration after peripheral nerve lesion in a transgenic mouse strain." dans: Journal of neurochemistry, Vol. 114, Issue 4, pp. 1007-18, (2010) (PubMed).

Tong, Wong, Guttman, Ang, Forno, Shimadzu, Rajput, Muenter, Kish, Hornykiewicz, Furukawa: "Brain alpha-synuclein accumulation in multiple system atrophy, Parkinson's disease and progressive supranuclear palsy: a comparative investigation." dans: Brain : a journal of neurology, Vol. 133, Issue Pt 1, pp. 172-88, (2010) (PubMed).

Cole, Dieuliis, Leo, Mitchell, Nussbaum: "Mitochondrial translocation of alpha-synuclein is promoted by intracellular acidification." dans: Experimental cell research, Vol. 314, Issue 10, pp. 2076-89, (2008) (PubMed).

Colapinto, Mila, Giraudo, Stefanazzi, Molteni, Rossetti, Bergamasco, Lopiano, Fasano: "alpha-Synuclein protects SH-SY5Y cells from dopamine toxicity." dans: Biochemical and biophysical research communications, Vol. 349, Issue 4, pp. 1294-300, (2006) (PubMed).

Takamori, Holt, Stenius, Lemke, Grønborg, Riedel, Urlaub, Schenck, Brügger, Ringler, Müller, Rammner, Gräter, Hub, De Groot, Mieskes, Moriyama, Klingauf, Grubmüller, Heuser, Wieland, Jahn: "Molecular anatomy of a trafficking organelle." dans: Cell, Vol. 127, Issue 4, pp. 831-46, (2006) (PubMed).

Steinacker, Schwarz, Reim, Brechlin, Jahn, Kratzin, Aitken, Wiltfang, Aguzzi, Bahn, Baxter, Brose, Otto: "Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein." dans: Molecular and cellular biology, Vol. 25, Issue 4, pp. 1339-46, (2005) (PubMed).

Détail du antigène

Antigène: Alpha, beta Synuclein

Autre désignation: alpha/beta Synuclein

Sujet:

Synonyms: alpha/beta Synuclein, SNCA, SNCB, NACP, Synuclein

Antigen Information: Synucleins are involved in Parkinson's and Alzheimer's Disease

UniProt: P37840