Abeta-pE3 (AA 3-7) anticorps

N° du produit ABIN1742433

Cité dans 2 publications. Cet anticorps anti-Abeta-pE3 Monoclonal Souris (Clone 1-57) (ABIN1742433) détecte spécifiquement Abeta-pE3 dans IHC (p) et WB. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Abeta-pE3 (AA 3-7) anticorps (ABIN1742433)

Antigène: Abeta-pE3

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)

Clone: 1-57

Détail du produit

Épitope: AA 3-7

Fonction: Mouse anti-Abeta-pE3 IgG

Specificité: Specific for Abeta-pE3.

Réactivité croisée (Details): Reacts with: human (P05067), rat (P08592), mouse (P12023). Other species not tested yet.

Purification: purified IgG

Immunogène: Synthetic peptide corresponding to AA 3 to 7 from human Abeta-pE3 (UniProt Id: P05067) Epitop AA 3 to 5 from human Abeta-pE3 (UniProt Id: P05067)

Isotype: IgG2b

Information d'application

Indications d'application: WB:1 : 1000 ICC:not tested yet IHC:not tested yet IHC-P:1 : 1000 up to 1 : 5000,

Commentaires:

WB: Detects purified Abeta pE3. Complex samples like brain extracts still have to be tested.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: For reconstitution add 100 μLH2O to get a 1 mg/mL solution in PBS.

Buffer: PBS. Albumin and azide were added for stabilization.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze! Antibodies should be stored at +4°C when still lyophilized.

Stock: -20 °C,-80 °C,4 °C

Stockage commentaire: Antibodies should be stored at +4°C when still lyophilized. Then aliquot and store at -20°C to -80°C until use. Albumin and azide were added for stabilization. Do not freeze!

Référence

Antonios, Saiepour, Bouter, Richard, Paetau, Verkkoniemi-Ahola, Lannfelt, Ingelsson, Kovacs, Pillot, Wirths, Bayer: "N-truncated Abeta starting with position four: early intraneuronal accumulation and rescue of toxicity using NT4X-167, a novel monoclonal antibody." dans: Acta neuropathologica communications, Vol. 1, Issue 1, pp. 56, (2013) (PubMed).

Wittnam, Portelius, Zetterberg, Gustavsson, Schilling, Koch, Demuth, Blennow, Wirths, Bayer: "Pyroglutamate amyloid β (Aβ) aggravates behavioral deficits in transgenic amyloid mouse model for Alzheimer disease." dans: The Journal of biological chemistry, Vol. 287, Issue 11, pp. 8154-62, (2012) (PubMed).

Détail du antigène

Antigène: Abeta-pE3

Sujet:

Synonyms: pE3-Abeta, pyro-Glu-Abeta, pGlu-Abeta, Abeta(3(pE)-40/42), pyro-Abeta

Antigen Information: Abeta peptides are major components of neuritic plaques in Alzheimer's disease

UniProt: P05067