Abeta 38/40/42 (AA 1-16) anticorps

N° du produit ABIN1742437

Cet anticorps Souris Monoclonal détecte spécifiquement Abeta 38/40/42 dans IHC, IHC (p), ELISA et WB. Il présente une réactivité avec des échantillons de Humain et Souris. Il a été cité dans 2+ publications.

Aperçu rapide pour Abeta 38/40/42 (AA 1-16) anticorps (ABIN1742437)

Antigène: Abeta 38/40/42

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)

Clone: NT78

Détail du produit

Épitope: AA 1-16

Fonction: Mouse anti-Abeta38/40/42/43 IgG

Specificité: Specific for Abeta 38, 40, 42.

Réactivité croisée (Details): Reacts with: human (P05067), mouse (P12023). Other species not tested yet.

Purification: purified IgG

Immunogène: Synthetic peptide corresponding to AA 1 to 16 from human Abeta (UniProt Id: P05067) Epitop AA 4 to 16 from human Abeta (UniProt Id: P05067)

Isotype: IgG2b

Information d'application

Indications d'application: WB:1 : 500 up to 1 : 1000 ,

Commentaires:

ELISA: Suitable as capture antibody for sandwich-ELISA as detector antibody (protocol for sandwich-ELISA).

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: For reconstitution add 100 μLH2O to get a 1 mg/mL solution in PBS.

Buffer: PBS. Azide was added before lyophilization.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze! Antibodies should be stored at +4°C when still lyophilized.

Stock: -20 °C,-80 °C,4 °C

Stockage commentaire: Antibodies should be stored at +4°C when still lyophilized. Then aliquot and store at -20°C to -80°C until use. Do not freeze!

Référence

Jawhar, Wirths, Schilling, Graubner, Demuth, Bayer et al.: "Overexpression of glutaminyl cyclase, the enzyme responsible for pyroglutamate A{beta} formation, induces behavioral deficits, and glutaminyl cyclase knock-out rescues the behavioral phenotype in ..." dans: The Journal of biological chemistry, Vol. 286, Issue 6, pp. 4454-60, (2011) (PubMed).

Wirths, Erck, Martens, Harmeier, Geumann, Jawhar, Kumar, Multhaup, Walter, Ingelsson, Degerman-Gunnarsson, Kalimo, Huitinga, Lannfelt, Bayer: "Identification of low molecular weight pyroglutamate A{beta} oligomers in Alzheimer disease: a novel tool for therapy and diagnosis." dans: The Journal of biological chemistry, Vol. 285, Issue 53, pp. 41517-24, (2010) (PubMed).

Détail du antigène

Antigène: Abeta 38/40/42

Sujet:

Synonyms: Beta-APP, ABPP, Abeta, Abeta 38, Abeta 40, Abeta 42, Abeta 43

Antigen Information: Abeta peptides are major components of neuritic plaques in Alzheimer's disease

UniProt: P05067