Abeta 38/40/42 (AA 1-16), (AA 4-8) anticorps

N° du produit ABIN1742439

Cet anticorps anti- est un anticorps Souris Monoclonal détectant dans IHC et WB. Adapté pour Humain et Souris. Ce Primary Antibody a été cité dans 4+ publications.

Aperçu rapide pour Abeta 38/40/42 (AA 1-16), (AA 4-8) anticorps (ABIN1742439)

Antigène: Abeta 38/40/42

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Clone: NT244

Détail du produit

Épitope: AA 1-16, AA 4-8

Specificité: Specific for Abeta 38, 40, 42.

Immunogène: Synthetic peptide (aa 1-16) of abeta peptides 38, 40, 42 coupled to key-hole limpet hemocyanin via an added C-terminal cysteine residue. Epitope aa 4-8

Isotype: IgG2b

Information d'application

Indications d'application: WB: 1:500 up to 1:1000 (ECL detection), ICC: 1:500, IHC: 1:500 up to 1:1000, ,

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: For reconstitution add 100µl H2O to get a 1mg/ml solution in PBS.

Buffer: PBS. Azide was added before lyophilization.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze! Antibodies should be stored at +4°C when still lyophilized.

Stock: -20 °C

Stockage commentaire: Reconstitute and aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized.

Référence

Porcellotti, Fanelli, Fracassi, Sepe, Cecconi, Bernardi, Cimini, Cerù, Moreno: "Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer's Disease." dans: Oxidative medicine and cellular longevity, Vol. 2015, pp. 967203, (2015) (PubMed).

Reinert, Martens, Huettenrauch, Kolbow, Lannfelt, Ingelsson, Paetau, Verkkoniemi-Ahola, Bayer, Wirths: "Aβ38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models." dans: Journal of Alzheimer's disease : JAD, Vol. 39, Issue 4, pp. 871-81, (2014) (PubMed).

Wirths, Hillmann, Pradier, Härtig, Bayer: "Oligomeric pyroglutamate amyloid-β is present in microglia and a subfraction of vessels in patients with Alzheimer's disease: implications for immunotherapy." dans: Journal of Alzheimer's disease : JAD, Vol. 35, Issue 4, pp. 741-9, (2013) (PubMed).

Venkataramani, Wirths, Budka, Härtig, Kovacs, Bayer: "Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregates." dans: Journal of Alzheimer's disease : JAD, Vol. 29, Issue 2, pp. 361-71, (2012) (PubMed).

Détail du antigène

Antigène: Abeta 38/40/42