MUC16 anticorps (Extracellular Domain)

N° du produit ABIN1804607

Détail du produit anti-MUC16 anticorps

Antigène: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Épitope: Extracellular Domain

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MUC16 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Marque: IHC-plus™

Specificité: Recognizes the ovarian cancer mucin CA125 (also known as MUC16). CA125 consists of a short cytoplasmic tail, a transmembrane domain and an exceptionally large glycosylated extracellular domain. The extracellular domain is dominated by a large number of 156-amino acid repeat units, over 60 in all. These repeats are known to bind the antibodies OC125 and M11. CA125 is present within normal ovarian, endometrium, endocervix and fallopian tissue, but levels are elevated in over 90 % of women with advanced ovarian cancer. CA125 levels may also be elevated in other cancers and non-cancerous conditions such as peritonitis, endometriosis and liver cirrhosis. Levels may also fluctuate during the menstrual cycle and occasionally increases in pregnancy, making CA125 an unreliable marker for ovarian cancer in premenopausal women. The function of CA125 in healthy tissue is unknown but it is thought to provide a protective lubricating barrier against particles and infectious agents at mucosal surfaces. CA125 was concluded by the International Society of Oncology and BioMarkers (ISOBM) to contain two major antigenic domains. Recognizes the epitope specificity group B, similar to the M-11 antibody. May be used to detect CA125 in ELISA assays.

Purification: Ion exchange chromatography

Immunogène: CA125 antigen purified from human ovarian carcinoma.

Clone: X325

Isotype: IgG1

Information d'application

Indications d'application: Approved: ELISA, IHC, IHC-P (10 μg/mL), WB

Usage: ELISA: This product may be used in an indirect ELISA or as a detection antibody in a sandwich ELISA together with LS-B2829 as a capture reagent.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Tris buffered saline, 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C,-20 °C

Stockage commentaire: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Détails sur MUC16

Antigène: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Autre désignation: MUC16 / CA125 (CA125 Produits)

Synonymes: anticorps CA125, anticorps 1110008I14Rik, anticorps Ca125, anticorps Gm1480, anticorps RGD1308422, anticorps MUC16, anticorps mucin 16, cell surface associated, anticorps mucin 16, anticorps mucin-16, anticorps MUC16, anticorps Muc16, anticorps LOC476718, anticorps LOC712735

Sujet: Name/Gene ID: MUC16

Synonyms: MUC16, CA125 ovarian cancer antigen, CA125, CA-125, MUC-16, Mucin-16

ID gène: 94025

UniProt: Q8WXI7