Soluble Terminal Complement Complex (sC5b-9) anticorps

N° du produit ABIN181111

Cet anticorps Souris Monoclonal détecte spécifiquement Soluble Terminal Complement Complex dans FACS, IHC (fro), WB et EIA. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Soluble Terminal Complement Complex (sC5b-9) anticorps (ABIN181111)

Antigène: Soluble Terminal Complement Complex (sC5b-9)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: 3R2-0

Détail du produit

Attributs du produit: Synonyms: Terminal complement complex, Membrane attack complex

Purification: Affinity Chromatography on Protein A

Isotype: IgG2b

Information d'application

Indications d'application: ELISA. Western Blot. Flow Cytometry. Immunohistochemistry on frozen sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Borate buffered saline, pH 8.4 containing 0.09 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détail du antigène

Antigène: Soluble Terminal Complement Complex (sC5b-9)

Autre désignation: Complement SC5b-9 (TCC / MAC)

Sujet: Both the classical and alternative complement pathways result in the formation of the cytolysis inducing C5b-9 complex. This complex is composed of 190 kDa C5b which is bound to cells via 71 kDa C9. Sublytic assembly of C5b-9 on plasma membranes induces cell cycle activation and survival. The binding of C5b-9 to the 75 kDa S-protein (or vitronectin) in the fluid phase prevents C5b-9 from assembling on the plasma membrane, deactivating it and forming the SC5b-9 complex. SC5b-9 is stable in vitro and is therefore a reliable indicator of terminal complement pathway activation.Synonyms: Membrane attack complex, Terminal complement complex