Soluble Terminal Complement Complex (sC5b-9) anticorps

N° du produit ABIN181111

Cet anticorps Souris Monoclonal détecte spécifiquement dans FACS, IHC (fro), WB et EIA. Il présente une réactivité envers Humain.

Aperçu rapide pour Soluble Terminal Complement Complex (sC5b-9) anticorps (ABIN181111)

Antigène: Soluble Terminal Complement Complex (sC5b-9)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: 3R2-0

Détail du produit

Attributs du produit: Synonyms: Terminal complement complex, Membrane attack complex

Purification: Affinity Chromatography on Protein A

Isotype: IgG2b

Information d'application

Indications d'application: ELISA. Western Blot. Flow Cytometry. Immunohistochemistry on frozen sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Borate buffered saline, pH 8.4 containing 0.09 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Date de péremption: 12 months

Détail du antigène

Antigène: Soluble Terminal Complement Complex (sC5b-9)

Autre désignation: Complement SC5b-9 (TCC / MAC)

Sujet: Both the classical and alternative complement pathways result in the formation of the cytolysis inducing C5b-9 complex. This complex is composed of 190 kDa C5b which is bound to cells via 71 kDa C9. Sublytic assembly of C5b-9 on plasma membranes induces cell cycle activation and survival. The binding of C5b-9 to the 75 kDa S-protein (or vitronectin) in the fluid phase prevents C5b-9 from assembling on the plasma membrane, deactivating it and forming the SC5b-9 complex. SC5b-9 is stable in vitro and is therefore a reliable indicator of terminal complement pathway activation.Synonyms: Membrane attack complex, Terminal complement complex