IL23R anticorps (AA 59-87)

N° du produit ABIN1819424

L’anticorps Chèvre Polyclonal anti-IL23R a été validé pour WB, IHC et IHC (p). Il convient pour détecter IL23R dans des échantillons de Humain et Souris.

Aperçu rapide pour IL23R anticorps (AA 59-87) (ABIN1819424)

Antigène: IL23R (Interleukin 23 Receptor (IL23R))

Reactivité: Humain, Souris

Hôte: Chèvre

Clonalité: Polyclonal

Conjugué: Cet anticorp IL23R est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-IL23R anticorps

Épitope: AA 59-87

Specificité: Recognizes the human interleukin-23 receptor (IL-23R). The interleukin-23 receptor is 629 amino acid ~72kD single pass type I transmembrane glycoprotein belonging to the type I cytokine receptor family and possessing two domains. Multiple potential isoforms formed by alternative splicing are described. Recognizes an epitope within the N-terminal (NT) region of Interleukin-23 receptor (IL-23R), present in isoforms 1, 3 and 4, the antibody is not expected to recognize other truncated forms of the receptor lacking the immunogen sequence. IL-23R is a mediator of T-cell, NK cell, and possibly macrophage/myeloid cell, stimulation acting as the receptor for IL-23, by association with the beta component of IL-12R and is thought to signal through activation of the JAK-STAT signalling pathway. Genetic variation in IL23R is associated with inflammatory bowel disease type 17 and susceptibility to the ulcerative and inflammatory psoriasis. Is reported as suitable for use in immunocytochemistry on acetone fixed cells and has been used successfully for the immunohistochemical localization of IL-23R in formalin fixed, paraffin embedded human tissues.

Purification: Affinity purified

Immunogène: Synthetic peptide CQPRKLHFYKNGIKERFQITRINKTTARL corresponding to amino acids 59-87 within the N-terminal region of human IL-23 receptor. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan (100%), Marmoset, Dog (97%), Gibbon, Monkey, Panda (93%), Ferret, Bovine, Cat, Horse, Pig (90%).

Type of Immunogen: Synthetic peptide

Isotype: IgG

Information d'application

Indications d'application: Approved: IHC, IHC-P (1:125), WB (1:500)

Usage: Use in IHC requires heat treatment prior to staining.

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.1 % sodium azide, 0.1 % BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: 4°C or -20°C, Avoid freeze-thaw cycles.

Détails sur IL23R

Antigène: IL23R (Interleukin 23 Receptor (IL23R))

Autre désignation: IL23R

Sujet: Name/Gene ID: IL23R
Family: Interleukin

Synonyms: IL23R, IL-23 receptor, Interleukin 23 receptor, IBD17, IL-23R, Interleukin-23 receptor

ID gène: 149233

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation