Factor VIII anticorps

N° du produit ABIN1820031

Détail du produit anti-Factor VIII anticorps

Antigène: Factor VIII (F8) (Coagulation Factor VIII (F8))

Reactivité: Humain, Porc

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Factor VIII est non-conjugé

Application: Western Blotting (WB), ELISA, Radioimmunoassay (RIA)

Specificité: Recognizes human Factor VIII, an essential blood coagulation factor. Whilst circulating in the blood, it is mostly stably complexed to von Willebrand factor. It is activated through cleavage at various sites, dissociates from the complex and interacts with Factor IXa, in the presence of calcium ions and phospholipids, to convert Factor X to the activated Factor Xa, which activates thrombin. Thrombin cleaves fibrinogen into fibrin, which polymerises and cross-links to form a blood clot. The activated Factor VIII is proteolytically inactivated and cleared from the bloodstream. Defects in Factor VIII cause hemophilia A, a disorder characterized by the body's inability to control blood clotting. This could result in severe blood loss, even with minor injuries. Clone RFF-VIIIC/8 is a very potent coagulation inhibitor. It recognizes an epitope towards the N-terminus of full-length Factor VIII. It also recognizes the 210kD, 90kD and 40kD cleavage products. This clone does not cross-react with von Willebrand factor.

Aucune reactivité croisée: Souris, Chien, Rat (Rattus)

Purification: Protein G purified

Immunogène: Affinity purified human Factor VIII.

Type of Immunogen: Purified protein

Clone: RFF-VIIIC-8

Isotype: IgG1

Information d'application

Indications d'application: Approved: ELISA (1:500 - 1:15000), RIA, WB

Commentaires:

Target Species of Antibody: Human

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: 4°C or -20°C, Avoid freeze-thaw cycles.

Détails sur Factor VIII

Antigène: Factor VIII (F8) (Coagulation Factor VIII (F8))

Autre désignation: F8 / FVIII / Factor VIII (F8 Produits)

Synonymes: anticorps fb61d02, anticorps wu:fb61d02, anticorps Cf-8, anticorps Cf8, anticorps FVIII, anticorps AHF, anticorps DXS1253E, anticorps F8B, anticorps F8C, anticorps HEMA, anticorps coagulation factor VIIi, anticorps coagulation factor VIII, anticorps coagulation factor VIII, procoagulant component, anticorps f7i, anticorps F8

Sujet: Name/Gene ID: F8

Synonyms: F8, AHF, Antihemophilic factor, Coagulation factor VIIIc, Coagulation factor VIII, DXS1253E, Factor VIII F8B, FVIII, HEMA, F8B, Factor VIII, Procoagulant component, F8C

ID gène: 2157