S1PR1 anticorps (C-Term)

N° du produit ABIN187786

Cet anticorps Lapin Polyclonal détecte spécifiquement S1PR1 dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour S1PR1 anticorps (C-Term) (ABIN187786)

Antigène: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp S1PR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-S1PR1 anticorps

Épitope: C-Term

Specificité: Reacts with human endothelial cell differentiation gene 1 (C-terminal), EDG-1. In Western blotting, detects an approximately 44 kDa band in RH7777 cells transfected with full length human EDG-1. For positive control, use RH7777 cells transfected with full length EDG-1. Species Reactivity: Human, other species not tested.

Stérilité: 0.2 μm filtered

Immunogène: Synthetic peptide derived from the C-terminal of EDG-1 receptor.

Information d'application

Indications d'application: Western blotting: Use at 5-10 µg/ml using a human EDG-1 receptor transfected cell line. The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Buffer: Rabbit polyclonal antibody against human endothelial cell differentiation gene 1 (CT). 100 µl of 1 mg/ml purified antibody 0.2 µm sterile filtered in phosphate buffered saline with 0.08% sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Détails sur S1PR1

Antigène: S1PR1 (Sphingosine-1-Phosphate Receptor 1 (S1PR1))

Autre désignation: EDG-1 / S1P1

Sujet: EDG-1 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-1 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. The couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-1 is expressed in cardiovascular, leukocyte containing and other tissues.

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2