LPAR1 anticorps (C-Term)

N° du produit ABIN187787

L’anticorps Lapin Polyclonal anti-LPAR1 a été validé pour WB. Il convient pour détecter LPAR1 dans des échantillons de Humain et Rat.

Aperçu rapide pour LPAR1 anticorps (C-Term) (ABIN187787)

Antigène: LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LPAR1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-LPAR1 anticorps

Épitope: C-Term

Specificité: Reacts with EDG-2. Species Reactivity: Human and Rat. Other species not tested.

Stérilité: 0.2 μm filtered

Immunogène: KLH conjugated synthetic peptide corresponding to the AA 328-344 of human EDG-2.

Information d'application

Restrictions: For Research Use only

Stockage

Buffer: Rabbit polyclonal antibody against human endothelial cell differentiation gene 2 (CT). This antibody is provided as a 0.2 µm sterile-filtered solution in PBS with 0.08% sodium azide at a concentration of 1 mg/mL. Assayed to be >95% purity by SDS PAGE.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur LPAR1

Antigène: LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

Autre désignation: EDG-2 / LPAR1

Sujet: Endothelial cell differentiation gene-2 (EDG-2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG-2, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduction decreases in c[AMP]i through Gi and increases in [Ca+2]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG-2 receptors (with EDG-4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.

Pathways: Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration