LPAR1 anticorps (C-Term)

N° du produit ABIN187787

Détail du produit anti-LPAR1 anticorps

Antigène: LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

Épitope: C-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LPAR1 est non-conjugé

Application: Western Blotting (WB)

Specificité: Reacts with EDG-2. Species Reactivity: Human and Rat. Other species not tested.

Stérilité: 0.2 μm filtered

Immunogène: KLH conjugated synthetic peptide corresponding to the AA 328-344 of human EDG-2.

Information d'application

Restrictions: For Research Use only

Stockage

Buffer: Rabbit polyclonal antibody against human endothelial cell differentiation gene 2 (CT). This antibody is provided as a 0.2 µm sterile-filtered solution in PBS with 0.08% sodium azide at a concentration of 1 mg/mL. Assayed to be >95% purity by SDS PAGE.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur LPAR1

Antigène: LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

Autre désignation: EDG-2 / LPAR1 (LPAR1 Produits)

Synonymes: anticorps EDG2, anticorps GPR26, anticorps Gpcr26, anticorps LPA1, anticorps Mrec1.3, anticorps VZG1, anticorps edg-2, anticorps rec.1.3, anticorps vzg-1, anticorps Edg2, anticorps EDG-2, anticorps 5031439C20, anticorps AI326300, anticorps Kdt2, anticorps lpA1, anticorps edg2, anticorps si:dz22b13.1, anticorps si:dz46m7.1, anticorps zgc:92157, anticorps LPA receptor 1-A, anticorps LPA-1-A, anticorps gpr26, anticorps lpa1, anticorps lpa1r, anticorps lpa1r1, anticorps lpar1, anticorps lpar1-a, anticorps lpar1-b, anticorps vzg1, anticorps xLPA1-1, anticorps LPA receptor 1-B, anticorps LPA-1-B, anticorps edg2-A, anticorps xLPA1-2, anticorps xlpa1R, anticorps lysophosphatidic acid receptor 1, anticorps lysophosphatidic acid receptor 1 S homeolog, anticorps lysophosphatidic acid receptor 1 L homeolog, anticorps LPAR1, anticorps Lpar1, anticorps lpar1, anticorps lpar1.S, anticorps lpar1.L

Sujet: Endothelial cell differentiation gene-2 (EDG-2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG-2, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduction decreases in c[AMP]i through Gi and increases in [Ca+2]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG-2 receptors (with EDG-4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.

Pathways: Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration