S1PR4 anticorps (C-Term)

N° du produit ABIN187788

Cet anticorps anti-S1PR4 Polyclonal Lapin (ABIN187788) détecte spécifiquement S1PR4 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour S1PR4 anticorps (C-Term) (ABIN187788)

Antigène: S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp S1PR4 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-S1PR4 anticorps

Épitope: C-Term

Specificité: Reacts with EDG-6. Species Reactivity: Human, other species not tested. Positive Control: RH7777 cells transfected with EDG-6 protein. The optimal dilution for a specific application should be determined by the researcher.

Stérilité: 0.2 μm filtered

Immunogène: Synthetic peptide derived from the C-terminal of the EDG-6 receptor.

Information d'application

Indications d'application: Western Blot: Use at 5-10 µg/ml using a human EDG-6 receptor transfected cell line. Detects a band of approximately 45 kDa in Cos cells transfected with full length human EDG-6. Due to low expression of EDG receptors, we recommend using Pierce Femto Signal substrate for western blot development.

Restrictions: For Research Use only

Stockage

Buffer: 100 µg purified antibody at 1 mg/ml in PBS with 0.08% sodium azide. Solution was sterile filtered at 0.2 µm.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur S1PR4

Antigène: S1PR4 (Sphingosine-1-Phosphate Receptor 4 (S1PR4))

Autre désignation: EDG-6 / S1P4

Sujet: EDG-6 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG-6 is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG-6 is expressed in lymphoid and hematopoietic tissue and in the lungs. Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the EDG-6 receptor is the sphingosine 1-phosphate receptor-4 (S1P-4).