Angiomotin anticorps (pTyr599)

N° du produit ABIN1881054

Cet anticorps anti-Angiomotin est un anticorps Lapin Polyclonal détectant Angiomotin dans DB. Adapté pour Humain. Ce Primary Antibody a été cité dans 5+ publications.

Aperçu rapide pour Angiomotin anticorps (pTyr599) (ABIN1881054)

Antigène: Angiomotin (AMOT)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Angiomotin est non-conjugé

Application: Dot Blot (DB)

Clone: RB41443

Détail du produit anti-Angiomotin anticorps

Épitope: pTyr599

Homologie: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This AMOT Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y599 of human AMOT.

Isotype: Ig Fraction

Information d'application

Indications d'application: DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-Angiomotin (ABIN1881054)

Heller, Adu-Gyamfi, Smith-Kinnaman, Babbey, Vora, Xue, Bittman, Stahelin, Wells: "Amot recognizes a juxtanuclear endocytic recycling compartment via a novel lipid binding domain." dans: The Journal of biological chemistry, Vol. 285, Issue 16, pp. 12308-20, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." dans: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Gagné, Moreau, Plourde, Lapointe, Lord, Gagnon, Fernandes: "Human angiomotin-like 1 associates with an angiomotin protein complex through its coiled-coil domain and induces the remodeling of the actin cytoskeleton." dans: Cell motility and the cytoskeleton, Vol. 66, Issue 9, pp. 754-68, (2009) (PubMed).

Zheng, Vertuani, Nyström, Audebert, Meijer, Tegnebratt, Borg, Uhlén, Majumdar, Holmgren: "Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis." dans: Circulation research, Vol. 105, Issue 3, pp. 260-70, (2009) (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." dans: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

Détails sur Angiomotin

Antigène: Angiomotin (AMOT)

Autre désignation: AMOT

Sujet: This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire: 118085

NCBI Accession: NP_001106962, NP_573572

UniProt: Q4VCS5

Pathways: Cell-Cell Junction Organization, Regulation of Cell Size