ASCL1 anticorps (N-Term)

N° du produit ABIN1881074

L’anticorps Lapin Polyclonal anti-ASCL1 a été validé pour WB. Il convient pour détecter ASCL1 dans des échantillons de Humain. Il y a 5+ publications disponibles.

Aperçu rapide pour ASCL1 anticorps (N-Term) (ABIN1881074)

Antigène: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASCL1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB41522

Détail du produit anti-ASCL1 anticorps

Épitope: AA 63-90, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ASCL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human ASCL1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-ASCL1 (ABIN1881074)

Phi, Kim, Eun, Wang, Park, Choi, Kim, Park, Cho, Kim: "Upregulation of SOX2, NOTCH1, and ID1 in supratentorial primitive neuroectodermal tumors: a distinct differentiation pattern from that of medulloblastomas." dans: Journal of neurosurgery. Pediatrics, Vol. 5, Issue 6, pp. 608-14, (2010) (PubMed).

McGaughey, McCallion: "Efficient discovery of ASCL1 regulatory sequences through transgene pooling." dans: Genomics, Vol. 95, Issue 6, pp. 363-9, (2010) (PubMed).

Li, Zhong, Li, Huang, Wang, Zheng, Zhang: "[Expression and clinicopathologic significance of human achaete-scute homolog 1 in pulmonary neuroendocrine tumors]." dans: Zhongguo fei ai za zhi = Chinese journal of lung cancer, Vol. 13, Issue 4, pp. 317-21, (2010) (PubMed).

Deng, Yang, Le, Deng, Xu, Xiong, Zhu, Xie, Song, Jankovic: "Examination of the MASH1 gene in patients with Parkinson's disease." dans: Biochemical and biophysical research communications, Vol. 392, Issue 4, pp. 548-50, (2010) (PubMed).

Improgo, Schlichting, Cortes, Zhao-Shea, Tapper, Gardner: "ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus." dans: Molecular cancer research : MCR, Vol. 8, Issue 2, pp. 194-203, (2010) (PubMed).

Détails sur ASCL1

Antigène: ASCL1 (Achaete-Scute Complex Homolog 1 (Drosophila) (ASCL1))

Autre désignation: ASCL1

Sujet: This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.

Poids moléculaire: 25454

NCBI Accession: NP_004307

UniProt: P50553

Pathways: Dopaminergic Neurogenesis