BRMS1 anticorps (N-Term)

N° du produit ABIN1881120

Cité dans 4 publications. Cet anticorps anti-BRMS1 Polyclonal Lapin (Clone RB40250) (ABIN1881120) détecte spécifiquement BRMS1 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour BRMS1 anticorps (N-Term) (ABIN1881120)

Antigène: BRMS1 (Breast Cancer Metastasis Suppressor 1 (BRMS1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRMS1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB40250

Détail du produit anti-BRMS1 anticorps

Épitope: AA 48-77, N-Term

Homologie: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This BRMS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-77 amino acids from the N-terminal region of human BRMS1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-BRMS1 (ABIN1881120)

Wu, McEwen, Harihar, Baker, DeWald, Zhou: "BRMS1 expression alters the ultrastructural, biomechanical and biochemical properties of MDA-MB-435 human breast carcinoma cells: an AFM and Raman microspectroscopy study." dans: Cancer letters, Vol. 293, Issue 1, pp. 82-91, (2010) (PubMed).

Vaidya, Sanchez, Kim, Welch: "Expression of the Breast Cancer Metastasis Suppressor 1 (BRMS1) maintains in vitro chemosensitivity of breast cancer cells." dans: Cancer letters, Vol. 281, Issue 1, pp. 100-7, (2009) (PubMed).

Frolova, Edmonds, Bodenstine, Seitz, Johnson, Feng, Welch, Frost: "A shift from nuclear to cytoplasmic breast cancer metastasis suppressor 1 expression is associated with highly proliferative estrogen receptor-negative breast cancers." dans: Tumour biology, Vol. 30, Issue 3, pp. 148-59, (2009) (PubMed).

Cicek, Fukuyama, Cicek, Sizemore, Welch, Sizemore, Casey: "BRMS1 contributes to the negative regulation of uPA gene expression through recruitment of HDAC1 to the NF-kappaB binding site of the uPA promoter." dans: Clinical & experimental metastasis, Vol. 26, Issue 3, pp. 229-37, (2009) (PubMed).

Détails sur BRMS1

Antigène: BRMS1 (Breast Cancer Metastasis Suppressor 1 (BRMS1))

Autre désignation: BRMS1

Sujet: This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.

Poids moléculaire: 28461

NCBI Accession: NP_056214

UniProt: Q9HCU9