CDKN3 anticorps (N-Term)

N° du produit ABIN1881194

Détail du produit anti-CDKN3 anticorps

Antigène: CDKN3 (Cyclin-Dependent Kinase Inhibitor 3 (CDKN3))

Épitope: AA 39-68, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDKN3 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This CDKN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-68 amino acids from the N-terminal region of human CDKN3.

Clone: RB42328

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-CDKN3 (ABIN1881194)

Jiang, Xia, Li, Deng, Zhao, Shi, Wang, Sun: "High expression levels of IKKalpha and IKKbeta are necessary for the malignant properties of liver cancer." dans: International journal of cancer. Journal international du cancer, Vol. 126, Issue 5, pp. 1263-74, (2010) (PubMed).

Shimada, Miyagawa, Kawashima, Tanaka, Honda, Honda, Tokunaga: "An approach based on a genome-wide association study reveals candidate loci for narcolepsy." dans: Human genetics, Vol. 128, Issue 4, pp. 433-41, (2010) (PubMed).

Okamoto, Kitabayashi, Taya: "KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction." dans: Biochemical and biophysical research communications, Vol. 351, Issue 1, pp. 216-22, (2006) (PubMed).

Hsieh, Yao, Lai, Yang: "Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1." dans: Biochemical and biophysical research communications, Vol. 349, Issue 2, pp. 573-81, (2006) (PubMed).

Chinami, Yano, Yang, Salahuddin, Moriyama, Shiroishi, Turner, Shirakawa, Adra et al.: "Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP..." dans: The Journal of biological chemistry, Vol. 280, Issue 17, pp. 17235-42, (2005) (PubMed).

Détails sur CDKN3

Antigène: CDKN3 (Cyclin-Dependent Kinase Inhibitor 3 (CDKN3))

Autre désignation: CDKN3 (CDKN3 Produits)

Synonymes: anticorps CDI1, anticorps CIP2, anticorps KAP, anticorps KAP1, anticorps CDKN3, anticorps 2410006H10Rik, anticorps K24G6.15, anticorps K24G6_15, anticorps KIP-RELATED PROTEIN 3, anticorps KRP3, anticorps inhibitor/interactor with cyclin-dependent kinase, anticorps cyclin dependent kinase inhibitor 3, anticorps cyclin-dependent kinase inhibitor 3, anticorps inhibitor/interactor with cyclin-dependent kinase, anticorps CDKN3, anticorps cdkn3, anticorps Cdkn3, anticorps ICK6

Sujet: The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 23805

NCBI Accession: NP_001124323, NP_005183

UniProt: Q16667