DCLK2 anticorps (N-Term)

N° du produit ABIN1881253

Cet anticorps Lapin Polyclonal détecte spécifiquement DCLK2 dans WB. Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour DCLK2 anticorps (N-Term) (ABIN1881253)

Antigène: DCLK2 (Doublecortin-Like Kinase 2 (DCLK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DCLK2 est non-conjugé

Application: Western Blotting (WB)

Clone: RB41922

Détail du produit anti-DCLK2 anticorps

Épitope: AA 167-196, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This DCLK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-196 amino acids from the N-terminal region of human DCLK2.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-DCLK2 (ABIN1881253)

Dijkmans, van Hooijdonk, Fitzsimons, Vreugdenhil: "The doublecortin gene family and disorders of neuronal structure." dans: Central nervous system agents in medicinal chemistry, Vol. 10, Issue 1, pp. 32-46, (2010) (PubMed).

Kerjan, Koizumi, Han, Dubé, Djakovic, Patrick, Baram, Heinemann, Gleeson: "Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 16, pp. 6766-71, (2009) (PubMed).

Gorelik, Sapir, Reiner: "Gene trapping: an antibody-dependent approach for verifying integration in your favorite gene." dans: Cellular & molecular biology letters, Vol. 13, Issue 4, pp. 614-20, (2008) (PubMed).

Détails sur DCLK2

Antigène: DCLK2 (Doublecortin-Like Kinase 2 (DCLK2))

Autre désignation: DCLK2

Sujet: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.

Poids moléculaire: 83606

NCBI Accession: NP_001035350, NP_001035351

UniProt: Q8N568