MTA1 anticorps (C-Term)

N° du produit ABIN1881556

Cet anticorps Lapin Polyclonal détecte spécifiquement MTA1 dans WB. Il présente une réactivité envers Humain, Souris et Rat et a été mentionné dans 5+ publications.

Aperçu rapide pour MTA1 anticorps (C-Term) (ABIN1881556)

Antigène: MTA1 (Metastasis Associated 1 (MTA1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MTA1 est non-conjugé

Application: Western Blotting (WB)

Clone: RB40949

Détail du produit anti-MTA1 anticorps

Épitope: AA 659-687, C-Term

Homologie: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This MTA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 659-687 amino acids from the C-terminal region of human MTA1.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-MTA1 (ABIN1881556)

Zhu, Guo, Li, Ding, Chen: "Metastasis-associated protein 1 nuclear expression is associated with tumor progression and clinical outcome in patients with non-small cell lung cancer." dans: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Vol. 5, Issue 8, pp. 1159-66, (2010) (PubMed).

Van Rechem, Boulay, Pinte, Stankovic-Valentin, Guérardel, Leprince: "Differential regulation of HIC1 target genes by CtBP and NuRD, via an acetylation/SUMOylation switch, in quiescent versus proliferating cells." dans: Molecular and cellular biology, Vol. 30, Issue 16, pp. 4045-59, (2010) (PubMed).

Yang, Liu, Li: "[Expression of Mta-1 and VEGF and their correlation in the endometrial cancer]." dans: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, Vol. 26, Issue 7, pp. 682-4, (2010) (PubMed).

Li, Ohshiro, Khan, Kumar: "Requirement of MTA1 in ATR-mediated DNA damage checkpoint function." dans: The Journal of biological chemistry, Vol. 285, Issue 26, pp. 19802-12, (2010) (PubMed).

Li, Pakala, Reddy, Ohshiro, Peng, Lian, Fu, Kumar: "Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway." dans: The Journal of biological chemistry, Vol. 285, Issue 13, pp. 10044-52, (2010) (PubMed).

Détails sur MTA1

Antigène: MTA1 (Metastasis Associated 1 (MTA1))

Autre désignation: MTA1

Sujet: This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling. [provided by RefSeq].

Poids moléculaire: 80786

NCBI Accession: NP_001190187, NP_004680

UniProt: Q13330

Pathways: Chromatin Binding