NXT1 anticorps (C-Term)

N° du produit ABIN1881591

Détail du produit anti-NXT1 anticorps

Antigène: NXT1 (NTF2-Related Export Protein 1 (NXT1))

Épitope: AA 85-111, C-Term

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NXT1 est non-conjugé

Application: Western Blotting (WB)

Homologie: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This NXT1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-111 amino acids from the C-terminal region of human NXT1.

Clone: RB30598

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-NXT1 (ABIN1881591)

Venkatesan, Rual, Vazquez, Stelzl, Lemmens, Hirozane-Kishikawa, Hao, Zenkner, Xin, Goh, Yildirim, Simonis, Heinzmann, Gebreab, Sahalie, Cevik, Simon, de Smet, Dann, Smolyar, Vinayagam, Yu et al.: "An empirical framework for binary interactome mapping...." dans: Nature methods, Vol. 6, Issue 1, pp. 83-90, (2008) (PubMed).

Forler, Köcher, Rode, Gentzel, Izaurralde, Wilm: "An efficient protein complex purification method for functional proteomics in higher eukaryotes." dans: Nature biotechnology, Vol. 21, Issue 1, pp. 89-92, (2003) (PubMed).

Katahira, Straesser, Saiwaki, Yoneda, Hurt: "Complex formation between Tap and p15 affects binding to FG-repeat nucleoporins and nucleocytoplasmic shuttling." dans: The Journal of biological chemistry, Vol. 277, Issue 11, pp. 9242-6, (2002) (PubMed).

Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." dans: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).

Wiegand, Coburn, Zeng, Kang, Bogerd, Cullen: "Formation of Tap/NXT1 heterodimers activates Tap-dependent nuclear mRNA export by enhancing recruitment to nuclear pore complexes." dans: Molecular and cellular biology, Vol. 22, Issue 1, pp. 245-56, (2001) (PubMed).

Détails sur NXT1

Antigène: NXT1 (NTF2-Related Export Protein 1 (NXT1))

Autre désignation: NXT1 (NXT1 Produits)

Sujet: The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene.

NCBI Accession: NP_037380

UniProt: Q9UKK6