OTX2 anticorps (C-Term)

N° du produit ABIN1881611

L’anticorps Lapin Polyclonal anti-OTX2 a été validé pour WB et IHC (p). Il convient pour détecter OTX2 dans des échantillons de Humain. Il y a 5+ publications disponibles.

Aperçu rapide pour OTX2 anticorps (C-Term) (ABIN1881611)

Antigène: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OTX2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB17482

Détail du produit anti-OTX2 anticorps

Épitope: AA 261-289, C-Term

Homologie: X, Zf, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This OTX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 261-289 amino acids from the C-terminal region of human OTX2.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-OTX2 (ABIN1881611)

Masuda, Esumi: "SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium." dans: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 26933-44, (2010) (PubMed).

Chung, Licznerski, Alavian, Simeone, Lin, Martin, Vance, Isacson: "The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons." dans: Brain : a journal of neurology, Vol. 133, Issue Pt 7, pp. 2022-31, (2010) (PubMed).

Ashkenazi-Hoffnung, Lebenthal, Wyatt, Ragge, Dateki, Fukami, Ogata, Phillip, Gat-Yablonski: "A novel loss-of-function mutation in OTX2 in a patient with anophthalmia and isolated growth hormone deficiency." dans: Human genetics, Vol. 127, Issue 6, pp. 721-9, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." dans: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Gonzalez-Rodriguez, Pelcastre, Tovilla-Canales, Garcia-Ortiz, Amato-Almanza, Villanueva-Mendoza, Espinosa-Mattar, Zenteno: "Mutational screening of CHX10, GDF6, OTX2, RAX and SOX2 genes in 50 unrelated microphthalmia-anophthalmia-coloboma (MAC) spectrum cases." dans: The British journal of ophthalmology, Vol. 94, Issue 8, pp. 1100-4, (2010) (PubMed).

Détails sur OTX2

Antigène: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Autre désignation: OTX2

Sujet: This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development. Two transcript variants encoding distinct isoforms have been identified for this gene. Other alternative splice variants may exist, but their full length sequences have not been determined.

Poids moléculaire: 31636

NCBI Accession: NP_001257452, NP_001257453, NP_001257454, NP_068374, NP_758840

UniProt: P32243

Pathways: Dopaminergic Neurogenesis