This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This DANRE park7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the C-terminal region of DANRE park7.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Date de péremption
6 months
Bretaud, Allen, Ingham, Bandmann: "p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease." dans: Journal of neurochemistry, Vol. 100, Issue 6, pp. 1626-35, (2007) (PubMed).
Bai, Mullett, Garver, Hinkle, Burton: "Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons." dans: Brain research, Vol. 1113, Issue 1, pp. 33-44, (2006) (PubMed).
anticorps DJ-1, anticorps DJ1, anticorps CAP1, anticorps Dj1, anticorps SP22, anticorps dj1, anticorps zgc:103725, anticorps park7b, anticorps park7, anticorps park7a, anticorps Parkinsonism associated deglycase, anticorps Parkinson disease (autosomal recessive, early onset) 7, anticorps parkinson protein 7, anticorps parkinson protein 7 S homeolog, anticorps parkinson protein 7 L homeolog, anticorps PARK7, anticorps Park7, anticorps park7, anticorps park7.S, anticorps park7.L
Sujet
Protects cells against oxidative stress and cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone (By similarity). Protects dopaminergic neurons against cell death arising from oxidative stress and proteasome inhibition, probably by a TP53/p53-dependent mechanism.