Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

MSK2 anticorps (AA 481-508)

RPS6KA4 Reactivité: Humain WB Hôte: Lapin Polyclonal RB42814 unconjugated
N° du produit ABIN1881766
  • Antigène Voir toutes MSK2 (RPS6KA4) Anticorps
    MSK2 (RPS6KA4) (Ribosomal Protein S6 Kinase A4 (RPS6KA4))
    Épitope
    • 10
    • 10
    • 9
    • 7
    • 7
    • 7
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 481-508
    Reactivité
    • 65
    • 50
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 65
    • 1
    Lapin
    Clonalité
    • 65
    • 1
    Polyclonal
    Conjugué
    • 24
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    Cet anticorp MSK2 est non-conjugé
    Application
    • 34
    • 28
    • 16
    • 11
    • 9
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This RPS6KA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 481-508 amino acids from the Central region of human RPS6KA4.
    Clone
    RB42814
    Isotype
    Ig Fraction
    Top Product
    Discover our top product RPS6KA4 Anticorps primaire
  • Indications d'application
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Antigène
    MSK2 (RPS6KA4) (Ribosomal Protein S6 Kinase A4 (RPS6KA4))
    Autre désignation
    RPS6KA4 (RPS6KA4 Produits)
    Synonymes
    anticorps MSK2, anticorps RSK-B, anticorps 1110069D02Rik, anticorps 90kDa, anticorps AI848992, anticorps Msk2, anticorps mMSK2, anticorps ribosomal protein S6 kinase A4, anticorps ribosomal protein S6 kinase, polypeptide 4, anticorps RPS6KA4, anticorps Rps6ka4
    Sujet
    Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen-and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
    Poids moléculaire
    85606
    NCBI Accession
    NP_001006945, NP_003933
    UniProt
    O75676
Vous êtes ici:
Support technique