SGOL2 anticorps (AA 391-419)

N° du produit ABIN1881800

Détail du produit anti-SGOL2 anticorps

Antigène: SGOL2 (Shugoshin-Like 2 (SGOL2))

Épitope: AA 391-419

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SGOL2 est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SGOL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-419 amino acids from the Central region of human SGOL2.

Clone: RB42663

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-SGOL2 (ABIN1881800)

Tanno, Kitajima, Honda, Ando, Ishiguro, Watanabe: "Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres." dans: Genes & development, Vol. 24, Issue 19, pp. 2169-79, (2010) (PubMed).

Ross, Katzov-Eckert, Dubé, Brooks, Rassekh, Barhdadi, Feroz-Zada, Visscher, Brown, Rieder, Rogers, Phillips, Carleton, Hayden: "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy." dans: Nature genetics, Vol. 41, Issue 12, pp. 1345-9, (2009) (PubMed).

Lee, Kitajima, Tanno, Yoshida, Morita, Miyano, Miyake, Watanabe: "Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells." dans: Nature cell biology, Vol. 10, Issue 1, pp. 42-52, (2008) (PubMed).

Huang, Feng, Famulski, Rattner, Liu, Kao, Muschel, Chan, Yen: "Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments." dans: The Journal of cell biology, Vol. 177, Issue 3, pp. 413-24, (2007) (PubMed).

Kitajima, Sakuno, Ishiguro, Iemura, Natsume, Kawashima, Watanabe: "Shugoshin collaborates with protein phosphatase 2A to protect cohesin." dans: Nature, Vol. 441, Issue 7089, pp. 46-52, (2006) (PubMed).

Détails sur SGOL2

Antigène: SGOL2 (Shugoshin-Like 2 (SGOL2))

Autre désignation: SGOL2 (SGOL2 Produits)

Synonymes: anticorps SGO2, anticorps TRIPIN, anticorps 1110007N04Rik, anticorps 4932411A20Rik, anticorps 5730576N04Rik, anticorps AU018846, anticorps AV008062, anticorps D1Ertd8e, anticorps Tripin, anticorps shugoshin 2, anticorps shugoshin 2A, anticorps SGO2, anticorps Sgo2a

Sujet: Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation (By similarity). Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.

Poids moléculaire: 144739

NCBI Accession: NP_001153518, NP_689737

UniProt: Q562F6