USP14 anticorps (C-Term)

N° du produit ABIN1881985

Détail du produit anti-USP14 anticorps

Antigène: USP14 (Ubiquitin Specific Peptidase 14 (USP14))

Épitope: AA 355-383, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP14 est non-conjugé

Application: Western Blotting (WB)

Homologie: B, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This USP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-383 amino acids from the C-terminal region of human USP14.

Clone: RB41691

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-USP14 (ABIN1881985)

Hyrskyluoto, Bruelle, Lundh, Do, Kivinen, Rappou, Reijonen, Waltimo, Petersén, Lindholm, Korhonen: "Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1?." dans: Human molecular genetics, Vol. 23, Issue 22, pp. 5928-39, (2014) (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." dans: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).

Chen, Qin, Li, Walters, Wilson, Mei, Wilson: "The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 35, pp. 10909-19, (2009) (PubMed).

Nagai, Kadowaki, Maruyama, Takeda, Nishitoh, Ichijo: "USP14 inhibits ER-associated degradation via interaction with IRE1alpha." dans: Biochemical and biophysical research communications, Vol. 379, Issue 4, pp. 995-1000, (2009) (PubMed).

Mines, Goodwin, Limbird, Cui, Fan: "Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation." dans: The Journal of biological chemistry, Vol. 284, Issue 9, pp. 5742-52, (2009) (PubMed).

Koulich, Li, DeMartino: "Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome." dans: Molecular biology of the cell, Vol. 19, Issue 3, pp. 1072-82, (2008) (PubMed).

Détails sur USP14

Antigène: USP14 (Ubiquitin Specific Peptidase 14 (USP14))

Autre désignation: USP14 (USP14 Produits)

Synonymes: anticorps TGT, anticorps DDBDRAFT_0202821, anticorps DDBDRAFT_0237695, anticorps DDB_0202821, anticorps DDB_0237695, anticorps 2610005K12Rik, anticorps 2610037B11Rik, anticorps AW107924, anticorps C78769, anticorps ax, anticorps zgc:55949, anticorps wu:fk63d09, anticorps MGC81945, anticorps tgt, anticorps MGC69343, anticorps USP14, anticorps ubiquitin specific peptidase 14, anticorps peptidase C19 family protein, anticorps ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase), anticorps ubiquitin specific protease 14, anticorps ubiquitin specific peptidase 14 S homeolog, anticorps universal stress protein, anticorps Ubiquitin carboxyl-terminal hydrolase 14, anticorps USP14, anticorps usp14, anticorps Usp14, anticorps Bm1_28765, anticorps usp14.S, anticorps RR_RS06480, anticorps usp-14

Sujet: This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Poids moléculaire: 56069

NCBI Accession: NP_001032411, NP_005142

UniProt: P54578