YBX1 anticorps (AA 149-178)

N° du produit ABIN1882002

Cet anticorps anti-YBX1 est un anticorps Lapin Polyclonal détectant YBX1 dans WB et IF. Adapté pour Humain. Ce Primary Antibody a été cité dans 5+ publications.

Aperçu rapide pour YBX1 anticorps (AA 149-178) (ABIN1882002)

Antigène: YBX1 (Y Box Binding Protein 1 (YBX1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp YBX1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: RB41913

Détail du produit anti-YBX1 anticorps

Épitope: AA 149-178

Homologie: B, M, Rb, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This YBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-178 amino acids from the Central region of human YBX1.

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-YBX1 (ABIN1882002)

Osada, Uno, Mineta, Kameoka, Takahashi, Terao: "Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta." dans: Molecular ecology, Vol. 19, Issue 14, pp. 2884-95, (2010) (PubMed).

Yu, Yip, Tan, Thike, Matsumoto, Tsujimoto, Bay: "Y-box binding protein 1 is up-regulated in proliferative breast cancer and its inhibition deregulates the cell cycle." dans: International journal of oncology, Vol. 37, Issue 2, pp. 483-92, (2010) (PubMed).

Lovett, Cheng, Cape, Pollock, Mertens: "YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis." dans: Biochemical and biophysical research communications, Vol. 398, Issue 3, pp. 482-8, (2010) (PubMed).

Takahashi, Shimajiri, Izumi, Hirano, Kashiwagi, Yasuniwa, Wu, Han, Akiyama, Nishizawa, Sasaguri, Kohno: "Y-box binding protein-1 is a novel molecular target for tumor vessels." dans: Cancer science, Vol. 101, Issue 6, pp. 1367-73, (2010) (PubMed).

To, Fotovati, Reipas, Law, Hu, Wang, Astanehe, Davies, Lee, Stratford, Raouf, Johnson, Berquin, Royer, Eaves, Dunn: "Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance." dans: Cancer research, Vol. 70, Issue 7, pp. 2840-51, (2010) (PubMed).

Détails sur YBX1

Antigène: YBX1 (Y Box Binding Protein 1 (YBX1))

Autre désignation: YBX1

Sujet: Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability.

Poids moléculaire: 35924

NCBI Accession: NP_004550

UniProt: P67809

Pathways: Regulation of Muscle Cell Differentiation