TK2 anticorps (N-Term)

N° du produit ABIN1882141

Cet anticorps Lapin Polyclonal détecte spécifiquement TK2 dans WB. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour TK2 anticorps (N-Term) (ABIN1882141)

Antigène: TK2 (Thymidine Kinase 2, Mitochondrial (TK2))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Application: Western Blotting (WB)

Clone: RB5434

Détail du produit anti-TK2 anticorps

Épitope: AA 8-38, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This Thymidine Kinase 2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-38 amino acids from the N-terminal region of human Thymidine Kinase 2.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Détails sur TK2

Antigène: TK2 (Thymidine Kinase 2, Mitochondrial (TK2))

Sujet: Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs. Both recombinant and native forms of the enzyme have broad substrate specificity and complex kinetics, suggesting that it may play a role in the activation of chemotherapeutic nucleoside analogs. The highest levels of expression are observed in testis and ovary. The main supply of deoxyribonucleotides (dNTPs) for mitochondrial DNA synthesis comes from the salvage pathway initiated by deoxyguanosine kinase (DGK) and TK2. The association of mitochondrial DNA depletion with mutations in the genes encoding these 2 kinases suggests that the salvage pathway enzymes are involved in the maintenance of balanced mitochondrial dNTP pools.

Poids moléculaire: 31005

NCBI Accession: NP_001166114, NP_001166115, NP_001258864, NP_004605

UniProt: O00142

Pathways: Mitotic G1-G1/S Phases