TOLLIP anticorps (C-Term)

N° du produit ABIN1882142

Détail du produit anti-TOLLIP anticorps

Antigène: TOLLIP (Toll Interacting Protein (TOLLIP))

Épitope: AA 221-250, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TOLLIP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This TOLLIP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-250 amino acids from the C-terminal region of human TOLLIP.

Clone: RB4409

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-TOLLIP (ABIN1882142)

Chen, Choong, Lin, Philp, Wong, Ang, Tan, Loh, Hew, Shah, Druker, Chong, Lim: "Differential expression of novel tyrosine kinase substrates during breast cancer development." dans: Molecular & cellular proteomics : MCP, Vol. 6, Issue 12, pp. 2072-87, (2007) (PubMed).

Zhang, Ghosh: "Negative regulation of toll-like receptor-mediated signaling by Tollip." dans: The Journal of biological chemistry, Vol. 277, Issue 9, pp. 7059-65, (2002) (PubMed).

Bulut, Faure, Thomas, Equils, Arditi et al.: "Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and ..." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 2, pp. 987-94, (2001) (PubMed).

Burns, Clatworthy, Martin, Martinon, Plumpton, Maschera, Lewis, Ray, Tschopp, Volpe: "Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor." dans: Nature cell biology, Vol. 2, Issue 6, pp. 346-51, (2000) (PubMed).

Volpe, Clatworthy, Kaptein, Maschera, Griffin, Ray: "The IL1 receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex." dans: FEBS letters, Vol. 419, Issue 1, pp. 41-4, (1998) (PubMed).

Détails sur TOLLIP

Antigène: TOLLIP (Toll Interacting Protein (TOLLIP))

Autre désignation: TOLLIP (TOLLIP Produits)

Synonymes: anticorps IL-1RAcPIP, anticorps 4930403G24Rik, anticorps 4931428G15Rik, anticorps fk22a02, anticorps im:7145391, anticorps wu:fk22a02, anticorps zgc:76985, anticorps TOLLIP, anticorps GB17961, anticorps tollip, anticorps tollip1, anticorps tollipa, anticorps TOLIP, anticorps toll interacting protein, anticorps toll-interacting protein, anticorps toll-interacting protein-like, anticorps toll interacting protein L homeolog, anticorps toll interacting protein S homeolog, anticorps Toll-interleukine I receptor interacting protein I, anticorps TOLLIP, anticorps Tollip, anticorps tollip, anticorps LOC552034, anticorps LOC100169858, anticorps tollip.L, anticorps tollip.S, anticorps LOC100136122

Sujet: Toll like protein is a component of the signaling pathway of IL1 and Toll like receptors. It inhibits cell activation by microbial products. Tollip recruits IRAK1 to the IL1 receptor complex and inhibits IRAK1 phosphorylation and kinase activity. It oligomerizes and binds to TLR2 and the TLR4-MD2 complex via its C terminus. It exists as a complex with IRAK1 in unstimulated cells. Upon IL1 signaling, Tollip binds to the activated IL1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP. TOLLIP also interacts with TLR2 and TLR4, TOLLIP overexpression inhibits nuclear factor kappa-B (NFKB) activation in response to lipopolysaccharide and IL1B.

Poids moléculaire: 30282

NCBI Accession: NP_061882

UniProt: Q9H0E2