USP5 anticorps (N-Term)

N° du produit ABIN1882150

Cet anticorps Lapin Polyclonal détecte spécifiquement USP5 dans WB et IHC (p). Il présente une réactivité envers Humain et a été mentionné dans 4+ publications.

Aperçu rapide pour USP5 anticorps (N-Term) (ABIN1882150)

Antigène: USP5 (Ubiquitin Specific Peptidase 5 (USP5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp USP5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB4271

Détail du produit anti-USP5 anticorps

Épitope: AA 59-90, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This USP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-90 amino acids from the N-terminal region of human USP5.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-USP5 (ABIN1882150)

Yoshioka, Ye, Okada, Taniguchi, Yoshida, Sugaya, Onose, Koshino, Takahashi, Yajima, Yajima, Abe: "Ubiquitin-specific peptidase 5, a target molecule of vialinin A, is a key molecule of TNF-α production in RBL-2H3 cells." dans: PLoS ONE, Vol. 8, Issue 12, pp. e80931, (2013) (PubMed).

Ouyang, Ali, Ravichandran, Dong, Qiu, MacKenzie, Dhe-Paganon, Arrowsmith, Zhai: "Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini." dans: The Journal of biological chemistry, Vol. 287, Issue 4, pp. 2317-27, (2012) (PubMed).

Falquet, Paquet, Frutiger, Hughes, Hoang-Van, Jaton: "cDNA cloning of a human 100 kDa de-ubiquitinating enzyme: the 100 kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2)." dans: FEBS letters, Vol. 376, Issue 3, pp. 233-7, (1996) (PubMed).

Falquet, Paquet, Frutiger, Hughes, Hoang-Van, Jaton: "A human de-ubiquitinating enzyme with both isopeptidase and peptidase activities in vitro." dans: FEBS letters, Vol. 359, Issue 1, pp. 73-7, (1995) (PubMed).

Détails sur USP5

Antigène: USP5 (Ubiquitin Specific Peptidase 5 (USP5))

Autre désignation: USP5

Sujet: Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.

Poids moléculaire: 95786

NCBI Accession: NP_001092006, NP_003472

UniProt: P45974