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USP5 anticorps (N-Term)

USP5 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB4271 unconjugated
N° du produit ABIN1882150
  • Antigène Voir toutes USP5 Anticorps
    USP5 (Ubiquitin Specific Peptidase 5 (USP5))
    Épitope
    • 13
    • 8
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 59-90, N-Term
    Reactivité
    • 44
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 39
    • 7
    Lapin
    Clonalité
    • 40
    • 6
    Polyclonal
    Conjugué
    • 26
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp USP5 est non-conjugé
    Application
    • 34
    • 23
    • 9
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogène
    This USP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-90 amino acids from the N-terminal region of human USP5.
    Clone
    RB4271
    Isotype
    Ig Fraction
    Top Product
    Discover our top product USP5 Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Yoshioka, Ye, Okada, Taniguchi, Yoshida, Sugaya, Onose, Koshino, Takahashi, Yajima, Yajima, Abe: "Ubiquitin-specific peptidase 5, a target molecule of vialinin A, is a key molecule of TNF-α production in RBL-2H3 cells." dans: PLoS ONE, Vol. 8, Issue 12, pp. e80931, (2013) (PubMed).

    Ouyang, Ali, Ravichandran, Dong, Qiu, MacKenzie, Dhe-Paganon, Arrowsmith, Zhai: "Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini." dans: The Journal of biological chemistry, Vol. 287, Issue 4, pp. 2317-27, (2012) (PubMed).

    Falquet, Paquet, Frutiger, Hughes, Hoang-Van, Jaton: "cDNA cloning of a human 100 kDa de-ubiquitinating enzyme: the 100 kDa human de-ubiquitinase belongs to the ubiquitin C-terminal hydrolase family 2 (UCH2)." dans: FEBS letters, Vol. 376, Issue 3, pp. 233-7, (1996) (PubMed).

    Falquet, Paquet, Frutiger, Hughes, Hoang-Van, Jaton: "A human de-ubiquitinating enzyme with both isopeptidase and peptidase activities in vitro." dans: FEBS letters, Vol. 359, Issue 1, pp. 73-7, (1995) (PubMed).

  • Antigène
    USP5 (Ubiquitin Specific Peptidase 5 (USP5))
    Autre désignation
    USP5 (USP5 Produits)
    Synonymes
    anticorps ISOT, anticorps AA407472, anticorps ISOT-1, anticorps Ucht, anticorps ubiquitin specific peptidase 5, anticorps ubiquitin carboxyl-terminal hydrolase 5, anticorps ubiquitin carboxyl-terminal hydrolase 5, putative, anticorps ubiquitin specific protease 5, anticorps ubiquitin specific peptidase 5 (isopeptidase T), anticorps USP5, anticorps CNH02890, anticorps EHI_049940, anticorps CC1G_12961, anticorps MCYG_01862, anticorps CGB_L3600C, anticorps PY00546, anticorps Usp5
    Sujet
    Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
    Poids moléculaire
    95786
    NCBI Accession
    NP_001092006, NP_003472
    UniProt
    P45974
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