ATG4C anticorps (AA 167-196)

N° du produit ABIN1882159

Cet anticorps Lapin Polyclonal détecte spécifiquement ATG4C dans WB et IHC (p). Il présente une réactivité envers Humain et a été mentionné dans 2+ publications.

Aperçu rapide pour ATG4C anticorps (AA 167-196) (ABIN1882159)

Antigène: ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG4C est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB7497

Détail du produit anti-ATG4C anticorps

Épitope: AA 167-196

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ATG4C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-196 amino acids from the Central region of human ATG4C.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-ATG4C (ABIN1882159)

Li, Hou, Wang, Chen, Shao, Yin: "Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates." dans: The Journal of biological chemistry, Vol. 286, Issue 9, pp. 7327-38, (2011) (PubMed).

Shintani, Klionsky: "Autophagy in health and disease: a double-edged sword." dans: Science (New York, N.Y.), Vol. 306, Issue 5698, pp. 990-5, (2004) (PubMed).

Détails sur ATG4C

Antigène: ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))

Autre désignation: ATG4C

Sujet: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4 is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

Poids moléculaire: 52497

NCBI Accession: NP_116241, NP_835739

UniProt: Q96DT6

Pathways: Autophagy