ATG4C anticorps (C-Term)

N° du produit ABIN1882160

Il existe 3+ publications pour ce produit. L’anticorps anti-ATG4C Polyclonal Lapin est utilisé pour la détection de ATG4C dans des échantillons de Humain et Souris. Il a été validé pour WB et IHC (p).

Aperçu rapide pour ATG4C anticorps (C-Term) (ABIN1882160)

Antigène: ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG4C est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB7499

Détail du produit anti-ATG4C anticorps

Épitope: AA 419-448, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogène: This ATG4C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 419-448 amino acids from the C-terminal region of human ATG4C.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-ATG4C (ABIN1882160)

Ma, Panda, Lin: "Temporal orchestration of circadian autophagy rhythm by C/EBP?." dans: The EMBO journal, Vol. 30, Issue 22, pp. 4642-51, (2012) (PubMed).

Norman, Cohen, Bampton: "The in vitro cleavage of the hAtg proteins by cell death proteases." dans: Autophagy, Vol. 6, Issue 8, pp. 1042-56, (2010) (PubMed).

Shintani, Klionsky: "Autophagy in health and disease: a double-edged sword." dans: Science (New York, N.Y.), Vol. 306, Issue 5698, pp. 990-5, (2004) (PubMed).

Détails sur ATG4C

Antigène: ATG4C (Autophagy related 4C Cysteine Peptidase (ATG4C))

Autre désignation: ATG4C

Sujet: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4 is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

Poids moléculaire: 52497

NCBI Accession: NP_116241, NP_835739

UniProt: Q96DT6

Pathways: Autophagy