GSG2 anticorps (AA 323-352)

N° du produit ABIN1882168

Cet anticorps Lapin Polyclonal détecte spécifiquement GSG2 dans WB et IHC (p). Il présente une réactivité envers Humain et a été mentionné dans 3+ publications.

Aperçu rapide pour GSG2 anticorps (AA 323-352) (ABIN1882168)

Antigène: GSG2 (Germ Cell Associated 2 (Haspin) (GSG2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GSG2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB3404

Détail du produit anti-GSG2 anticorps

Épitope: AA 323-352

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Haspin GSG2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323~352 amino acids from the central region of human haspin.

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-GSG2 (ABIN1882168)

Dai, Sultan, Taylor, Higgins: "The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment." dans: Genes & development, Vol. 19, Issue 4, pp. 472-88, (2005) (PubMed).

Higgins: "The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells." dans: Gene, Vol. 267, Issue 1, pp. 55-69, (2001) (PubMed).

Tanaka, Iguchi, Nakamura, Kohroki, de Carvalho, Nishimune: "Cloning and characterization of human haspin gene encoding haploid germ cell-specific nuclear protein kinase." dans: Molecular human reproduction, Vol. 7, Issue 3, pp. 211-8, (2001) (PubMed).

Détails sur GSG2

Antigène: GSG2 (Germ Cell Associated 2 (Haspin) (GSG2))

Autre désignation: Haspin GSG2

Sujet: Post-translational modifications of conserved N-terminal tail residues in histones regulate many aspects of chromosome activity. Mitotic phosphorylation of H3 Thr 3 occurs in prophase and dephosphorylation during anaphase. Haspin, a dual serine/threonine kinase, plays an important role in regulation of chromosome and spindle function during mitosis and meiosis via its function in phosphorylation of the threonine residue in the third position of histone 3 (Thr3).

Poids moléculaire: 88495

NCBI Accession: NP_114171

UniProt: Q8TF76