FKBP4 anticorps (AA 1-177)

N° du produit ABIN1885705

Cet anticorps Lapin Polyclonal détecte spécifiquement FKBP4 dans WB, IHC et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour FKBP4 anticorps (AA 1-177) (ABIN1885705)

Antigène: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FKBP4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-FKBP4 anticorps

Épitope: AA 1-177

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 177 of FKBP52

Information d'application

Indications d'application: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.500
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 20 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: Biohazard Informations: This product contains thimerosal which is hazardous.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur FKBP4

Antigène: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Autre désignation: FKBP52

Sujet: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking.This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin.It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506.It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes.This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase.It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors.This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines.Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy.The human genome contains several non-transcribed pseudogenes similar to this gene.[provided by RefSeq]

Poids moléculaire: 52 kDa

ID gène: 2288

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway