TFIID(SI-1) (AA 158-339) anticorps

N° du produit ABIN1886075

L’anticorps anti-TFIID(SI-1) Polyclonal Lapin est utilisé pour la détection de TFIID(SI-1) dans des échantillons de Humain. Il a été validé pour IHC et WB.

Aperçu rapide pour TFIID(SI-1) (AA 158-339) anticorps (ABIN1886075)

Antigène: TFIID(SI-1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Détail du produit

Épitope: AA 158-339

Purification: Affinity purified by Protein A.

Immunogène: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 158 and 339 of Human TBP

Information d'application

Indications d'application: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: Biohazard Informations: This product contains thimerosal which is hazardous.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détail du antigène

Antigène: TFIID(SI-1)

Sujet: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides.The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals.TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs.TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation.This gene encodes TBP, the TATA-binding protein.A distinctive feature of TBP is a long string of glutamines in the N-terminal.This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription.Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.[provided by RefSeq]
Synonyms: GTF2D, SCA17, TFIID, GTF2D1, MGC117320, MGC126054, MGC126055

Poids moléculaire: 38 kDa

ID gène: 6908

NCBI Accession: NP_003185, NM_003194