MC1 Receptor anticorps (AA 253-317)

N° du produit ABIN1886268

Cet anticorps anti-MC1 Receptor est un anticorps Lapin Polyclonal détectant MC1 Receptor dans WB. Adapté pour Humain.

Aperçu rapide pour MC1 Receptor anticorps (AA 253-317) (ABIN1886268)

Antigène: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MC1 Receptor est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MC1 Receptor anticorps

Épitope: AA 253-317

Purification: Purified by antigen-affinity chromatography.

Immunogène: Synthetic peptide contain a sequence corresponding to a region within amino acids 253 and 317 of Human MC1R

Information d'application

Indications d'application: Suggested dilutions:
Western blotting: 1.500-1.3000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: Biohazard Informations: This product contains thimerosal which is hazardous.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Détails sur MC1 Receptor

Antigène: MC1 Receptor (MC1R) (Melanocortin 1 Receptor (MC1R))

Autre désignation: MC1-R

Sujet: This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH).The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis.Two types of melanin exist: red pheomelanin and black eumelanin.Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color.Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation.Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis.This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer.Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.[provided by RefSeq]
Synonyms: MSH-R, SHEP2, MGC14337

Poids moléculaire: 35 kDa

ID gène: 4157

NCBI Accession: NM_002386, NP_002377

Pathways: cAMP Metabolic Process, Feeding Behaviour