MTBP anticorps (AA 122-139)

N° du produit ABIN1886842

Cet anticorps Lapin Polyclonal détecte spécifiquement MTBP dans WB, ELISA et ICC. Il présente une réactivité envers Humain.

Aperçu rapide pour MTBP anticorps (AA 122-139) (ABIN1886842)

Antigène: MTBP (MDM2 Binding Protein (MTBP))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MTBP est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-MTBP anticorps

Épitope: AA 122-139

Purification: Affinity chromatography purified via peptide column

Immunogène: Synthetic peptide corresponding to amino acids 122 to 139 of human MTBP, which differ from the mouse sequence by three amino acids.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur MTBP

Antigène: MTBP (MDM2 Binding Protein (MTBP))

Autre désignation: MTBP

Sujet: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death.Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2 and MTBP, were recently discovered.The transcriptional activity of p53 is modulated by posttranslational regulations of the p53 protein including stabilization and acetylation.P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein.MDM2 inhibits both p53 mediated G1 arrest and apoptosis.A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53.MTBP is expressed in a variety of normal tissues.
Synonyms: MTBP

Poids moléculaire: 104 kDa

NCBI Accession: NP_071328