IRGC anticorps (N-Term)

N° du produit ABIN1887842

L’anticorps Lapin Polyclonal anti-IRGC a été validé pour WB, ELISA et ICC. Il convient pour détecter IRGC dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour IRGC anticorps (N-Term) (ABIN1887842)

Antigène: IRGC (Immunity-Related GTPase Family, Cinema (IRGC))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRGC est non-conjugé

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Détail du produit anti-IRGC anticorps

Épitope: N-Term

Specificité: Two isoforms of IRGC are known to exist, this antibody will only recognize the IRGCa isoform.

Purification: Affinity chromatography purified via peptide column

Immunogène: 13 amino acid peptide near the amino terminus of human IRGC.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur IRGC

Antigène: IRGC (Immunity-Related GTPase Family, Cinema (IRGC))

Autre désignation: IRGC

Sujet: Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens.IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans.Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs.In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines.As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.
Synonyms: Immunity-related GTPase cinema 1, Interferon-inducible GTPase 5, Iigp5, CINEMA

NCBI Accession: NP_062558