SIVA1 anticorps (N-Term)

N° du produit ABIN1888008

Cet anticorps anti-SIVA1 Polyclonal Lapin (ABIN1888008) détecte spécifiquement SIVA1 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour SIVA1 anticorps (N-Term) (ABIN1888008)

Antigène: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIVA1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-SIVA1 anticorps

Épitope: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogène: 16 amino acid peptide near the amino terminus of human SIVA.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur SIVA1

Antigène: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Autre désignation: SIVA

Sujet: SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily.SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure.The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway.SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFkappa-B and promotes T-cell receptor-mediated apoptosis.SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases.
Synonyms: SIVA1, apoptosis-inducing factor, CD27-binding protein, CD27BP, SIVA-1, SIVA-2

NCBI Accession: NP_068355

Pathways: Positive Regulation of Endopeptidase Activity