CCL20 anticorps

N° du produit ABIN192395

Il existe 6+ publications pour ce produit. L’anticorps anti-CCL20 Monoclonal Souris est utilisé pour la détection de CCL20 dans des échantillons de Humain. Il a été validé pour IP, FACS, IHC (p) et IHC (fro).

Aperçu rapide pour CCL20 anticorps (ABIN192395)

Antigène: CCL20 (Chemokine (C-C Motif) Ligand 20 (CCL20))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CCL20 est non-conjugé

Application: Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: UCHL1

Détail du produit anti-CCL20 anticorps

Fonction: Anti-Hu CD45R0 Purified

Réactivité croisée (Details): Human

Attributs du produit: The antibody UCHL1 recognizes an extracellular epitope of CD45R0, a 180 kDa low molecular weight isoform of the leukocyte common antigen (LCA). The antigen is expressed on a subset of memory/activated T cells and on cortical thymocytes.

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Human IL-2 dependent T cells

Isotype: IgG2a

Information d'application

Indications d'application: Immunohistochemistry (paraffin sections): This product does not require protein digestion pretreatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Positive tissue: tonsil.
Immunohistochemistry (frozen sections): Positive tissue: tonsil.
Flow cytometry: Recommended dilution: 10 μg/mL.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-CCL20 (ABIN192395)

Akbar, Terry, Timms, Beverley, Janossy: "Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 140, Issue 7, pp. 2171-8, (1988) (PubMed).

Beverley, Merkenschlager, Terry: "Phenotypic diversity of the CD45 antigen and its relationship to function." dans: Immunology. Supplement, Vol. 1, pp. 3-5, (1988) (PubMed).

Terry, Brown, Beverley: "The monoclonal antibody, UCHL1, recognizes a 180,000 MW component of the human leucocyte-common antigen, CD45." dans: Immunology, Vol. 64, Issue 2, pp. 331-6, (1988) (PubMed).

Beverley: "Human T cell subsets." dans: Immunology letters, Vol. 14, Issue 4, pp. 263-7, (1987) (PubMed).

Norton, Ramsay, Smith, Beverley, Isaacson: "Monoclonal antibody (UCHL1) that recognises normal and neoplastic T cells in routinely fixed tissues." dans: Journal of clinical pathology, Vol. 39, Issue 4, pp. 399-405, (1986) (PubMed).

Smith, Brown, Rowe, Callard, Beverley: "Functional subsets of human helper-inducer cells defined by a new monoclonal antibody, UCHL1." dans: Immunology, Vol. 58, Issue 1, pp. 63-70, (1986) (PubMed).

Détails sur CCL20

Antigène: CCL20 (Chemokine (C-C Motif) Ligand 20 (CCL20))

Autre désignation: CD45R0

Sujet: CD45R0 is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45R0 is expressed e.g. on macrophages, CD8+ T cells, activated T cells and myeloma cells.,PTPRCR, T200R0

ID gène: 35

Pathways: Phosphorylation & l'infection par le SRAS-CoV-2