SP1 anticorps (AA 1-250)

N° du produit ABIN1944791

L’anticorps Souris Monoclonal anti-SP1 a été validé pour WB, IF et FACS. Il convient pour détecter SP1 dans des échantillons de Humain. Il y a 2+ publications disponibles.

Aperçu rapide pour SP1 anticorps (AA 1-250) (ABIN1944791)

Antigène: SP1 (Sp1 Transcription Factor (SP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SP1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 1326CT463-109-176

Détail du produit anti-SP1 anticorps

Épitope: AA 1-250

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This SP1 antibody is generated from a mouse immunized with a recombination protein from the human SP1.

Isotype: IgG1 kappa

Information d'application

Indications d'application: IF: 1:25. WB: 1:1000. FC: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-SP1 (ABIN1944791)

Takahara, Kanazu, Yanagisawa, Akanuma: "Heterogeneous Sp1 mRNAs in human HepG2 cells include a product of homotypic trans-splicing." dans: The Journal of biological chemistry, Vol. 275, Issue 48, pp. 38067-72, (2000) (PubMed).

Kadonaga, Carner, Masiarz, Tjian: "Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain." dans: Cell, Vol. 51, Issue 6, pp. 1079-90, (1988) (PubMed).

Détails sur SP1

Antigène: SP1 (Sp1 Transcription Factor (SP1))

Autre désignation: SP1

Sujet: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR- alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression.

Poids moléculaire: 80693

ID gène: 6667

UniProt: P08047

Pathways: Regulation of Lipid Metabolism by PPARalpha, Myometrial Relaxation and Contraction