USP11 anticorps (N-Term)

N° du produit ABIN2838501

Il existe 4+ publications pour ce produit. L’anticorps anti-USP11 Monoclonal Souris est utilisé pour la détection de USP11 dans des échantillons de Humain. Il a été validé pour WB et FACS.

Aperçu rapide pour USP11 anticorps (N-Term) (ABIN2838501)

Antigène: USP11 (Ubiquitin Specific Peptidase 11 (USP11))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp USP11 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS)

Clone: 1220CT620-193-189

Détail du produit anti-USP11 anticorps

Épitope: AA 32-300, N-Term

Purification: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogène: This USP11 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 32-300 amino acids from the N-terminal region of human USP11.

Isotype: IgG1 kappa

Information d'application

Indications d'application: WB: 1:1000. FC: 1:25

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Date de péremption: 6 months

Références pour anticorps anti-USP11 (ABIN2838501)

Yamaguchi, Kimura, Miki, Yoshida: "The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha)." dans: The Journal of biological chemistry, Vol. 282, Issue 47, pp. 33943-8, (2007) (PubMed).

Schoenfeld, Apgar, Dolios, Wang, Aaronson: "BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage." dans: Molecular and cellular biology, Vol. 24, Issue 17, pp. 7444-55, (2004) (PubMed).

Ideguchi, Ueda, Tanaka, Yang, Tsuji, Ohno, Hagiwara, Aoki, Ishigatsubo: "Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM." dans: The Biochemical journal, Vol. 367, Issue Pt 1, pp. 87-95, (2002) (PubMed).

Swanson, Freund, Ploder, McInnes, Valle: "A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders." dans: Human molecular genetics, Vol. 5, Issue 4, pp. 533-8, (1996) (PubMed).

Détails sur USP11

Antigène: USP11 (Ubiquitin Specific Peptidase 11 (USP11))

Autre désignation: USP11

Sujet: Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks.

Poids moléculaire: 109817

ID gène: 8237

UniProt: P51784