Thrombomodulin anticorps

N° du produit ABIN1944809

Détail du produit anti-Thrombomodulin anticorps

Antigène: Thrombomodulin (THBD)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Thrombomodulin est non-conjugé

Application: Western Blotting (WB)

Isotype: IgG1

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Stock: 4 °C,-20 °C

Références pour anticorps anti-Thrombomodulin (ABIN1944809)

Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." dans: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).

Shirai, Shiojiri, Ito, Yamamoto, Kusumoto, Deyashiki, Maruyama, Suzuki: "Gene structure of human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein C." dans: Journal of biochemistry, Vol. 103, Issue 2, pp. 281-5, (1988) (PubMed).

Suzuki, Kusumoto, Deyashiki, Nishioka, Maruyama, Zushi, Kawahara, Honda, Yamamoto, Horiguchi: "Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation." dans: The EMBO journal, Vol. 6, Issue 7, pp. 1891-7, (1987) (PubMed).

Jackman, Beeler, Fritze, Soff, Rosenberg: "Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 18, pp. 6425-9, (1987) (PubMed).

Wen, Dittman, Ye, Deaven, Majerus, Sadler: "Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene." dans: Biochemistry, Vol. 26, Issue 14, pp. 4350-7, (1987) (PubMed).

Détails sur Thrombomodulin

Antigène: Thrombomodulin (THBD)

Autre désignation: THBD (THBD Produits)

Synonymes: anticorps AHUS6, anticorps BDCA3, anticorps CD141, anticorps THPH12, anticorps THRM, anticorps TM, anticorps AI385582, anticorps THBD, anticorps HAST, anticorps HAST3, anticorps M-PST, anticorps ST1A3/ST1A4, anticorps ST1A5, anticorps STM, anticorps TL-PST, anticorps thrombomodulin, anticorps sulfotransferase family 1A member 3, anticorps THBD, anticorps Thbd, anticorps SULT1A3

Sujet: Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

Poids moléculaire: 60329 Da

ID gène: 7056

UniProt: P07204